In the present paper, two new subclasses of analytic functions with respect to k-symmetric points defined by differential operator. Some interesting properties belonging to these classes are provided.

Luotonins and its derivatives (Isoluotonins) are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolinoquinoline alkaloids,. A few methods were known for the sysnthesis of Isoluotonin All luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against leukemia P-388 cells. Luotonin A is the most active one, with its activity stemming from topoisomerase I-dependent DNAcleavage. Such intriguing biological activities and unique structures have led not only to the development of synthetic methods for the efficient synthesis of these compounds, but also to interest in structural modifications for improving the biological properties. Recent progress in the study of luotonins is covered. 

Toyota, in Japan started the creation of this method in the early 1960's and hence it is also known as the “Toyota Production System” as it was used for their production of their automobiles. Therefore, the best definition of this system comes from Toyota i.e. JIT is a disciplined programme for improving overall productivity and reducing waste. It provides for the cost-effective production and delivery of only the necessary required parts, in the right quantity, at the right time and place, while using a minimum amount of facilities, equipment, materials and human resources. JIT is dependent upon the balance between the supplier's flexibility and user's stability. It is accomplished through the application of specific techniques that require total employee involvement and teamwork.

A new generalised derivative operator is introduced. This operator generalised many well-known operators studied earlier by many authors. New subclasses of analytic functions in the open unit disc are introduced which are defined using generalized derivative operator. Inclusion theorems are investigated for functions to be in the classes. Furthermore, generalised Bernardi-Libera-Livington integral operator is shown to be preserved for these classes.