Abstract

Periodontal disease is a multifactorial condition characterized by chronic inflammation and progressive destruction of supporting tissues, with significant implications for oral health and systemic well-being. This study investigated the correlation between inflammatory responses and regenerative outcomes in periodontal supporting tissues, emphasizing the role of epigenetic regulation. A mixed methods approach was employed, combining clinical assessments, patient-reported outcomes, and molecular analyses. Spearman correlation analysis revealed strong associations between clinical indicators of inflammation and perceived regenerative improvements, underscoring the interplay between destructive and reparative processes. Demographic and lifestyle factors, including smoking and systemic health conditions, were found to influence variability in responses. Regenerative therapies demonstrated favorable outcomes in terms of clinical attachment gain, alveolar bone support, and patient satisfaction. These findings highlight the importance of integrating epigenetic insights with clinical practice to develop personalized strategies for managing periodontal disease and enhancing tissue regeneration

Abstract Antimicrobial agents are widely used to treat bacterial infections; however, their misuse contributes to the growing problem of antibiotic resistance. This study assessed the prevalence of antibiotic resistance among bacterial isolates from patients in Gharyan City, Libya, and explored behavioral factors influencing resistance. Between January and June 2024, 66 clinical samples (urine, stool, vaginal swabs, blood, pus, and sputum) were collected from seven medical laboratories. A questionnaire survey was conducted among three groups: medical workers (n=50), non-medical individuals (n=50), and pharmacists (n=50). Laboratory identification employed selective media, Gram staining, and microscopy, while antibiotic susceptibility was tested using disc diffusion. Results revealed widespread inappropriate antibiotic use: 70% of pharmacists dispensed antibiotics without prescriptions, 40% provided incorrect dosages, and only 10% held formal pharmacy qualifications. Among medical workers, 40% used antibiotics without prescriptions and 56% failed to complete treatment courses. Infections were more common in females (77%) than males (23%), with the highest prevalence in younger age groups (<32 years, 39.4%). Staphylococcus spp (32%) and E. coli (27%) were the most frequent isolates. Overall resistance was high (75%), particularly in Pseudomonas spp (100%), E. coli (83%), and Staphylococcus spp (76%). Azithromycin (67%) and Doxycycline (49%) showed the highest resistance rates, while Meropenem (2%) and Nalidixic acid (3%) remained largely effective. These findings highlight alarming levels of antibiotic resistance in Gharyan, driven by misuse and poor prescribing practices. Strengthening pharmacist and physician training, enforcing prescription regulations, and raising public awareness are essential to mitigate resistance and preserve antibiotic efficacy. Keywords. Antibiotic Resistance, Bacterial Infection, Misuse of Antibiotics, Control and Surveillance.

While most pregnant women in Gharyan city demonstrated adequate oral health knowledge, gaps persist in

preventive practices, particularly regarding fluoride use and dental visits. Education level and dental visits

during pregnancy were significant determinants of knowledge. These findings highlight the need for targeted

oral health education programs and increased access to dental services for pregnant women to improve oral

health outcomes for both mothers and their infants.

Abstract Classroom presentations represent an important aspect of activities that help English as a Second Language learners showcase their language skills, particularly speaking in front of others, and reveal the educational and psychological obstacles and challenges they face in performing these presentations at the best possible level. The study aims to identify the impact of language anxiety on classroom presentations by applying it to English as Foreign Language learners at Gharian University, which helps to investigate the level and type of anxiety that English as a Foreign Language students at the university suffer from during presentations. The study was conducted on various students of different semesters at University. The sample consisted of 100 students of both genders, divided into two groups (45 males and 45 females), during the academic year 2025-2026. The study relied on a questionnaire as the data collection tool, and the collected data was statistically analyzed using SPSS software. The results showed a high level of anxiety about learning English among the participating students for various reasons. A statistically significant inverse relationship was found between the level of English language anxiety among University students and the quality of their classroom presentations. Statistically significant differences were also found in language anxiety levels among students during classroom presentations, while no statistically significant differences were found between gender and anxiety levels in terms of their impact on the quality of classroom presentations. The stuconcluded with recommendations and suggestions to enhance the

Abstract

Obesity and headache are conditions associated with a substantial personal and societal impact. This study aims to evaluate the association between body mass index (BMI) and Headache among adults in Gharyan City, Libya. This was a descriptive cross-sectional study, conducted at Gharyan city, Libya, during the period from December 2024 to March 2025. Two hundred (200) participants, including 94 males (47%) and 106 females (53%), were enrolled in this study. Data were collected by using a structured questionnaire. The participants were divided into four categories, based on BMI: underweight (<18.5), normal weight (18.5 to 24.9), overweight (25 to 29.9), and obese (>30). A total of 200 participants, both gender males and females, were enrolled in this study during the study period. The study indicates that high percentage of headache in age was 43 -56 years, and severe obesity BMI > 30 kg/m2 were observed of high percentage in females n=27 (25.47%) compared to males n=17 (18.08%), although the severe obesity and headache found in females n=37 (34.90%), rather than males n=30 (31.91%) Obesity and headache are both, slightly more common in females than males, we recommend that more studies among obesity and headache in large patients should be done, although small sample size and lack of long-term flow-up of patients, were the main limitations of our study and results suggested a need for monitoring by X-ray and MRI diagnosis of patients have obesity

Keywords. Obesity. Headache, Gharyan City, Libya.

شهدت المدن الليبية تحولات متسارعة نتيجة للنمو السريع، والذي عالبا ما حدث في غياب تخطيط عمراني محكم أدى هذا الوضع الى مخاوف بشأن الزحف العمراني وعدم المساواة في الوصول الى الخدمات.تقدم هذه الدراسة منهجية تعتمد على نظم المعلومات الجغرافية (GIS) لتتبع هذه التغيرات في مدينة طرابلس، ليبيا تستخدم بيانات مفتوحة المصدر حول الشكل الحضري، والغطاء الارضي، وأنماط الاستيطان، بالاضافة الى مواقع الخدمات العامة، قمت بقياس كيفية نمو طرابلس وتحديد المناطق التي تفتقر الى الخدمات.

تظهر صور الاقمار الصناعية والمقاييس المكانية نموا قويا في المناطف المبينة على مدى أربعة عقود، حيث ازداد الزحف العمراني حدة في العقد الاول من القرن الحادي والعشرين ارتفع مؤشر "شانون انثروبي من 0.74 في عام 1984 الى 0.90 في عام 2010 مما يشيرالى أن النمو أصبح أكثر تشتتا، وفي الوقت نفسه، شهدت المناطق الطرفية الجديدة زيادة سكانية دون توفر خدمات كافية، مما يضطر الكثير من السكان لقطع مسافات أطول للوصول الى الرعاية الصحية والمدارس.

قمت بدمج نقاط الخدمات من خرائط الشوارع المفتوحة مع الشبكات السكانية، ومن ثم رسمت خرائط لفجوات الخدمة لتحديد المناطق ذات التغطية الضعيفة، تظهر النتائج واضحا لعدم المساواة الخدمية، حيث تحتوي مناطق غير المخطط لها على أقل من المستشفيات والمدارس والمرافق لكل فرد، بينما تتمتع الاحياء المركزية المخططة بمستويات خدمة أفضل. تساعد هذه المنهجية المعتمدة على نظام المعلومات الجغرافية المخططين في رؤية شكل النمو فجوات الخدمة، كما تدعم اتخاذ قرارات تخطيطية أفضل، تختتم الدراسة بخطوات للتحكم في النمو بشكل أفضل واقترح التوسع الموجه والاستثمار الخدمي المركز، وهى خطوات يمكن أن تدعم نموا عادلا ومستداما في طرابلس والمدن المماثلة.

الكلمات الافتتاحية: التوسع الحضري- نظم المعلومات الجغرافيةGIS - عدم المساواة المكانية- المورفولوجيا الحضرية- امكانية الوصول للخدمات.

Abstract

Stem cell therapy has emerged as a promising approach for craniofacial bone remodeling and dental tissue regeneration. In this study, a mixed-methods design was employed, combining laboratory analyses with clinical data from 100 participants. Results demonstrated that 80% of respondents had received mesenchymal stem cell (MSC) therapy, with 70% reporting improvements in bone density and 65% noting enhanced dental tissue regeneration. Imaging tests confirmed progress in 85% of cases, while overall satisfaction with therapy outcomes was reported by 80–85% of participants. Correlation analysis revealed strong positive relationships between stem cell treatment and improvements in bone and dental tissues, with coefficients ranging from 0.60 to 0.70 (p < 0.01). Side effects were minimal, with only 20% reporting complications such as swelling or pain. These findings underscore the therapeutic potential of stem cell-based interventions, highlighting both their efficacy and safety. The study concludes that stem cell therapy represents a viable and effective strategy for regenerative dentistry and craniofacial surgery, though larger multicenter trials are needed to standardize protocols and validate long-term outcomes.