This paper proposes an estimation method based on the reflection of the (manifest) explanatory variable to estimate the parameters of a simple linear regression model when both response and explanatory variables are subject to measurement error (ME). The reflection method (RM) uses all observed data points, and does not exclude or ignore part of the data or replace them by their ranks. The RM is straightforward, and easy to implement. We show that the RM is equivalent or asymptotically equivalent to the orthogonal regression (OR) method. Simulation studies show that the RM produces estimators that are nearly asymptotically unbiased and efficient under the assumption that the ratio of the error variances equals one. Moreover, it allows to define the sum of squares of errors uniquely, the same way as in the case of no measurement error. Simulation based numerical comparisons of the RM with the ordinary least square (OLS) and OR methods are also included.

Given the pressing need for new antiprotozoal drugs without cross-resistance with current (failing) chemotherapy, we have explored 3-tridecylpyridinium alkaloids (3TPAs), derivatives of viscosamine, as antiparasitic agents. We have developed a simple synthetic route toward viscosamine and related cyclic and linear monomers and oligomers. Evaluation for cytotoxicity on the protozoan parasites Trypanosoma brucei, Leishmania spp., and Plasmodium falciparum revealed several 3TPAs with antiprotozoal activity in the nanomolar range. Their promising selectivity index in vitro prompted us to study the dynamics of cytotoxicity on trypanosomes in more detail. Parasites were killed relatively slowly at therapeutically safe concentrations, in a process that did not target the cell cycle. Clearance of T. brucei cultures was observed at drug concentrations of 1–10 μM.

Information Communication Technologies (ICTs) provide an opportunity to meet the growing needs of rural areas. Many of the key features of ICT can be used to provide information and the requirements of people in rural areas. The digital divide considered is an important problem that countries face and it is much more complex than simply building out telecommunication networks and infrastructure. The divide is the result of a wide range of social factors, including but not limited to economy factors, education, literacy. Telecommunication infrastructure alone will not guarantee that users will be able to access and take advantage of services on the network. The paper begins with an introduction to the digital divide, and thus to highlight several successful initiatives provided by educational institutions and governmental organizations in Libya in the adoption of ICT. Finally, the paper provides some of the solutions proposed to reduce this divide.

The present study was performed to evaluate the anti-schistosomal activity of the medicinal plant ginger Zingiber officinale. Mice were individually infected with 100 Schistosoma mansoni cercariae. Four weeks post-infection, mice were orally treated with 1200 mg/kg of ginger for ten consecutive days. After the last dose all animals were sacrificed to evaluate the efficacy of ginger in treatment of the infection. The results obtained showed moderate reduction of 16.5% in the worm burden compared with control infected animals. The liver egg count showed a marked reduction of 53.8%. Ginger treatment showed a significant reduction in the size of liver granuloma where a percentage reduction of 66.35 was observed. Ginger treatment was slightly reflected on the liver function at such rate of infection, where an improvement in serum arginase activity was recorded, while no appreciable improvement in hepatic ALT and AST activities, albumin and creatinine contents. In conclusion Z. officinale displayed some degree of anti-schistosomal activity through reducing of the S. mansoni eggs output and the liver granuloma size.

تمت إضافة ثلاثة أنواع نباتية للفلورا الليبية هي Ruta montana + Pimpinella cretica + plantago bellardii

تمت إضافة ثلاثة أنواع نباتية للفلورا الليبية هي Lactuca saligna + Sanguisorba minor